Holding On?

Holding on to peroxisomes

Yeast cells are known to actively partition organelles between the mother and bud during division. Mitochondria, for example, are subjected to both retention and ordered movement to ensure that a proper fraction of the organelles end up in each cell after cytokinesis. In the case of peroxisomes, researchers knew that a subset of the organelles moved into the bud in a myosin-dependent manner, bu...

Holding the lid on HIV.

Holding intruders accountable on the Internet

This paper addresses the problem of tracing intruders who obscure their identity by logging through a chain of multiple machines. After discussing previous approaches to this problem, we introduce thumbprints which are short summaries of the content of a connection. These can be compared to determine whether two connections contain the same text and are therefore likely to be part of the same c...

Holding the reins on myosin V.

M yosins comprise a diverse family of molecular motor enzymes that use the energy from cycles of ATP binding, hydrolysis, and product release to perform mechanical work along actin filaments. Although all characterized myosins share a conserved catalytic motor domain, referred to as ‘‘head,’’ variations in enzymatic and structural properties allow different myosins to generate diverse types of ...

Effect of temperature on handgrip holding time.

The effect of intramuscular temperature upon the holding time of 70% MVC handgrip contraction was studied in 12 college-age men. The intramuscular temperature was regulated by 30 minutes immersion of the forearm and hand in a waterbath at 18 degrees C, 35 degrees C, or 45 degrees C. Elevating intramuscular temperature significantly reduced the holding time duration, (25.7 +/- 6.2 vis 38.3 +/- 8...